Expert review byMolly Knudsen, MS, RDN
A note before you read: the product we ranked #1 is ours. We spent 17 years interviewing experts andtest productsfinding out what really works. When we can’t get enough glutathione, we make our own.
1
Very good overall
mindbodygreen – the ultimate multivitamin +
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Save 10% with codeROUNDUP
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Contains 100 mg of clinically studied Setria® glutathione
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Delivers 33 bioavailable vitamins, minerals, and phytonutrients to support the entire body
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Contains additional antioxidants such as resveratrol, lycopene, lutein, and zeaxanthin to complement the benefits of glutathione
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A very high dose
Codeage – Liposomal Glutathione
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Delivers 1,000 milligrams of liposomal glutathione
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Liposomal delivery to improve absorption
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Continuous release
Thorne – Glutathione-SR
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Continuous release technology for gradual delivery
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NSF Approved Sport®
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175 milligrams of glutathione
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The best liquid
Quicksilver Scientific – Liposomal Glutathione
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Fast-absorbing liquid liposomal formula
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They’re easy to take—no capsules are needed
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Cocoa mint or lemon mint flavor
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Best for CoQ10
Symbiotics – Liposomal Glutathione
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It provides NAC and other key precursors of glutathione
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Liposomal delivery system
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A complete antioxidant formula
Glutathione is often called the body’s “master antioxidant” because it is one of the most important compounds your cells use to protect against oxidative stress. Made of three amino acids—glutamine, glycine, and cysteine—glutathione is found in almost every cell of the body, with the highest concentration in the liver. Its main function is to neutralize free radicals, regenerate other antioxidants (such as vitamins C and E), and support the body’s natural detoxification processes.
Although your body makes its own glutathione, production naturally declines with age. Everyday factors such as poor sleep, chronic stress, alcohol, environmental toxins, excessive exercise, and nutrient deficiencies can also increase your need for this important antioxidant.
- Protect cells from oxidative stress and free radical damage*
- Support healthy liver function and natural detoxification*
- Recycle and regenerate other antioxidants, including vitamins C and E*
- Support immune function*
- Promote healthy aging by protecting mitochondria and cellular health*
What to look for in a glutathione supplement
Not all glutathione supplements are created equal. While some formulas provide glutathione directly, others contain glutathione precursors—nutrients like N-acetyl-L-cysteine (NAC), glycine, or selenium that help your body produce more glutathione.
That’s because regular oral glutathione isn’t always absorbed well. If you choose a supplement that contains glutathione itself, look for a form that has clinical research supporting its bioavailability, such asSetria® glutathione2which has been shown to raise blood and cellular glutathione levels in human subjects.
Other factors to consider include:
- Clinically studied ingredients and effective dosages
- Third party quality and purity testing
- Less fillers and unnecessary additives
- Added nutrients such as vitamin C or selenium, which help support the antioxidant activity of glutathione.
Who can benefit from a glutathione supplement?
While everyone relies on glutathione for healthy cellular function, supplementation may be especially helpful for people with high glutathione levels or needs, including:
- Seniors who want to support healthy aging and cellular resilience
- People exposed to high levels of environmental pollutants or oxidative stress
- They don’t always drink alcohol
- Athletes or very active people do not recover from intense exercise
- Anyone who wants to support healthy liver function and antioxidant defenses
If you are generally healthy and eat a diet rich in protein and colorful fruits and vegetables, your body probably produces glutathione naturally. However, because production declines with age and modern lifestyles can increase oxidative stress, many people choose to supplement with a well-absorbed supplement of glutathione or its important precursors to help support healthy levels over time.
Most glutathione supplements fall into one of two camps: they can provide glutathione precursors (like NAC) or glutathione itself. What makes mindbodygreen’s ultimate multivitamin+ stand out is that it contains 100 milligrams of Setria® glutathione—a patented, clinically tested form of reduced glutathione that has been shown to increase blood and cellular glutathione levels after oral administration. Unlike regular glutathione, which is not always well utilized by the body, Setria® has research supporting its bioavailability.
Thankfully, glutathione isn’t the only antioxidant that does the heavy lifting. The formula pairs Setria® with five additional longevity-focused antioxidants—including resveratrol, lycopene, lutein, zeaxanthin, and black pepper extract—as well as selenium and vitamin C, nutrients that help support the body’s antioxidant defense system.
As a bonus, you get much more than a glutathione supplement. The complete formula delivers 33 vitamins, minerals, and phytonutrients in highly bioavailable forms, making it an excellent choice for anyone looking to support healthy aging, cellular health, immune function, and wellness in one daily supplement.